Pericardial mesothelioma is known only to be caused by exposure to asbestos, a naturally occurring but toxic mineral that was used in industrial capacities. While the precise route by which microscopic asbestos fibers reaches the pericardial lining is not known, physicians surmise that inhaled asbestos fibers are absorbed into the bloodstream and become entangled in the heart's lining as the blood processes through the heart. Mesothelioma occurring in other parts of the body, such as in the pleura or peritoneum, can also metastasize to the pericardial lining.
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